LEADER 02345nam  2200277 n 450 
001 TD16000885
049   $aTDMAGDIG
100   $a20190501d2012------k--ita-50----ba 
101 1 $aeng
200 1 $aTHE CLINICAL AND BIOLOGICAL FEATURES OF A SERIES OF IMMUNOPHENOTYPIC VARIANT OF B-CLL$bTesi di dottorato
210  1$cUniversità degli Studi di Milano$d2012-01-18
300   $adiritti: info:eu-repo/semantics/closedAccess
328  0$btesi di dottorato$cSettore MED/15 - Malattie del Sangue$eUniversità degli Studi di Milano
330   $aWe described the clinical and biological features of  63 cases of immunophenotypic variant of B-CLL (v-CLL) characterised by intermediate RMH score, in absence of t(11;14)(q13;q32) in FISH analysis in comparison with 130 cases of typical CLL.  We observed significant differences in terms of age <70 yrs (p <.001), lymphocytosis <20 x 109/l (p <.001), lymphocyte doubling time <12 months (p = .02), high serum beta2-microglobulin levels (p <.001) and splenomegaly (p = .002); CD38, CD49d, CD1c were more expressed in v-CLL, CD43 in CLL (p <.001). IgVH mutation and trisomy 12 were more frequent in v-CLL group (p = .001; p<.001); del13q14 in CLL (p=.008). Gene expression profiling of nine v-CLL and 60 CLL indicated that the atypical group presented a specific molecular pattern. After a median follow-up of respectively 55 (4-196) and 60 months (6-180), 25/42 v-CLL (48%) and 55/93 CLL patients (59%) were treated. Time to treatment was significantly shorter in v-CLL when IgVH mutational status was considered (p= .006). The median overall survival was worse in v-CLL  mutated cases (p= 0.062).  In conclusion, v-CLL should be identified and dealt with separately from classic CLL. In particular, the prognostic markers that are routinely used to characterise classical B-CLL should not be interpreted as having the same meaning.
610 0 $aCLL
610 0 $aFlow cytometry
610 0 $aFluorescence in situ hybridization
689 0 $aSettore MED/15$b- Malattie del Sangue$cTDR
702  0$atutor: Luca Baldini ;
coordinatore: Paolo Corradini
702  0$aBALDINI, LUCA
702  0$aCORRADINI, PAOLO
801  3$aIT$bIT-FI0098
856 4 $uhttp://memoria.depositolegale.it/*/http://hdl.handle.net/2434/203768$2http://hdl.handle.net/2434/203768
997   $aCF
FMT   $aTD
FOR   $aTD