De Palo, Giovanna
Dynamics and adaptation in the olfactory and phototransduction pathways [Tesi di dottorato]
SISSA, 2012-10-29

Due to their function of “probes” of external stimuli, sensory systems have to be able to respond appropriately to a wide range of amplitudes of the input signal. The process by means of which they adjust their sensitivity to a stimulus is called adaptation. In the first part of the thesis we focus on the study of the olfactory transduction pathway, explaining the adaptation exhibited by this system, and introducing a model able to reproduce the features of the biological response. We then consider data obtained from phototransduction experiments and compare their properties with those of the olfactory system, unveiling a possible general mechanism used by these two pathways to achieve adaptation. Finally a detailed study of one of the ion channels involved in the olfactory transduction pathway, the calcium-activated chloride channel, is presented. We suggest a Markov scheme explaining the modulation of the activity of the channel by the transmembrane voltage and the calcium concentration.

diritti: info:eu-repo/semantics/openAccess
In relazione con info:eu-repo/semantics/altIdentifier/hdl/20.500.11767/4784
Altafini, Claudio
Menini, Anna

Tesi di dottorato. | Lingua: Inglese. | Paese: | BID: TD17042536